Mutagenic and genotoxic <i>in silico</i> QSAR prediction of dimer impurity of gliflozins; canagliflozin, dapaglifozin, and emphagliflozin and <i>in vitro</i> evaluation by Ames and micronucleus test-Reference-Cited by-同舟云学术

Mutagenic and genotoxic in silico QSAR prediction of dimer impurity of gliflozins; canagliflozin, dapaglifozin, and emphagliflozin and in vitro evaluation by Ames and micronucleus test

Published:2024-07-29 Issue: Volume: Page:1-10
ISSN:0148-0545
Container-title:Drug and Chemical Toxicology
language:en
Short-container-title:Drug and Chemical Toxicology

Author:

Rane Rajesh¹,Satpute Bharat¹,Kumar Dileep¹,Suryawanshi Mugdha¹,Prabhune Akshay Ganesh¹,Gawade Bapu²,Mahajan Anand³,Pawar Atmaram⁴,Sakat Sachin⁵

Affiliation:

1. Department of Pharmaceutical Chemistry, BVDU Poona College of Pharmacy, Pune, India

2. Director, Cleanchem Life Sciences Pvt. Ltd., Navi Mumbai, Maharashtra, India

3. Department of Pharmaceutical Chemistry, Goa College of Pharmacy, Panaji, Goa, India

4. Department of Pharmaceutics, BVDU Poona College of Pharmacy, Pune, India

5. Director, Shribios Innovations Pvt. Ltd, Pune, Maharashtra, India

Publisher

Informa UK Limited

Link

https://www.tandfonline.com/doi/pdf/10.1080/01480545.2024.2378768

Reference25 articles.

1. No Cytotoxic and Inflammatory Effects of Empagliflozin and Dapagliflozin on Primary Renal Proximal Tubular Epithelial Cells under Diabetic Conditions In Vitro

2. Validation of Toxtree and SciQSAR in silico predictive software using a publicly available benchmark mutagenicity database and their applicability for the qualification of impurities in pharmaceuticals

3. European Medicines Agency. (2020). Committee for Medicinal Products for Human Use (CHMP). Assessment report ranitidine. EMEA/H/A + 31/1491. https://www.ema.europa.eu/en/documents/referral/ranitidine-article-31-referral-assessment-report_en.pdf

4. Sodium-Glucose Cotransporter 2 Inhibitors Mechanisms of Action: A Review

5. Hydromorphone impurity 2,2-bishydromorphone does not exert mutagenic and clastogenic properties via in silico QSAR prediction and in vitro Ames and micronucleus test