Orientation affects the integrity of glass ampoules of 1 in 1000 adrenaline on exposure to very low temperatures
Author:
Affiliation:
1. British Antarctic Survey Medical Unit, Plymouth, UK
2. Academic Department of Military Emergency Medicine, Royal Centre for Defence Medicine, Birmingham, UK
Publisher
Informa UK Limited
Link
https://www.tandfonline.com/doi/pdf/10.1080/22423982.2024.2309756
Reference6 articles.
1. The Impact of Freeze-Thaw Cycles on Epinephrine
2. Epinephrine autoinjectors: Does freezing or refrigeration affect epinephrine dose delivery and enantiomeric purity?
3. Mechanistic studies of glass vial breakage for frozen formulations. II. Vial breakage caused by amorphous protein formulations;Jiang G;PDA J Pharm Sci Technol,2007
4. Adrenaline (epinephrine) 1mg/ml (1: 1000) solution for injection (ampoule);Martindale Pharma;Sum Prod Charact,2019
5. THE EFFECTS OF FREEZING ON EPINEPHRINE AUTO-INJECTOR DEVICE FUNCTION
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1. Repeated freezing to very low temperatures does not impact the amount ejected from EpiPen® and Jext® adrenaline autoinjectors;International Journal of Circumpolar Health;2024-06-14
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