Single-cell analysis of arthritogenic alphavirus-infected human synovial fibroblasts links low abundance of viral RNA to induction of innate immunity and arthralgia-associated gene expression

Author:

Pott Fabian12ORCID,Postmus Dylan12,Brown Richard J. P.3ORCID,Wyler Emanuel4,Neumann Elena5,Landthaler Markus46,Goffinet Christine12ORCID

Affiliation:

1. Institute of Virology, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

2. Berlin Institute of Health at Charité, Universitätsmedizin Berlin, Berlin, Germany

3. Division of Veterinary Medicine, Paul Ehrlich Institute, Langen, Germany

4. Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin Institute for Medical Systems Biology (BIMSB), Berlin, Germany

5. Internal Medicine and Rheumatology, Justus-Liebig-University Giessen, Bad Nauheim, Germany

6. IRI Life Sciences, Institut für Biologie, Humboldt Universität zu Berlin, Berlin, Germany

Funder

Deutsche Forschungsgemeinschaft

Publisher

Informa UK Limited

Subject

Virology,Infectious Diseases,Drug Discovery,General Medicine,Immunology,Microbiology,Parasitology,Epidemiology

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