A single mutation in the cis-acting replication element identified within the EV-A71 2C-coding region causes defects in virus production in cell culture

Author:

Xi Juemin1,Ma Chunxia1,Wei Zhizhong2,Yin Bin2,Zhao Siwen1,Quan Wenqi1,Yang Jing1,Yuan Jiangang2,Qiang Boqin2,Ye Fei23,Peng Xiaozhong12

Affiliation:

1. Institute of Medical Biology, Chinese Academy of Medical Sciences, and Peking Union Medical College, Kunming, People’s Republic of China

2. The State Key Laboratory of Medical Molecular Biology, Department of Molecular Biology and Biochemistry, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China

3. NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control & Prevention, Chinese Center for Disease Control and Prevention, China CDC, Beijing, People’s Republic of China

Funder

National Key Research

CAMS

Natural Science Foundation of Yunnan Province

High-level Health Technology Special Talent Project of Yunnan Province

Key Project of Institute of Medical Biology

Chinese Academy of Medical Sciences

Publisher

Informa UK Limited

Subject

Virology,Infectious Diseases,Drug Discovery,General Medicine,Immunology,Microbiology,Parasitology,Epidemiology

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