Antibody persistence and safety after heterologous boosting with orally aerosolised Ad5-nCoV in individuals primed with two-dose CoronaVac previously: 12-month analyses of a randomized controlled trial

Author:

Jin Lairun1,Tang Rong2,Wu Shipo3,Guo Xiling2,Huang Haitao4,Hou Lihua3,Chen Xiaoqin5,Zhu Tao4,Gou Jinbo4,Zhong Jin5,Pan Hongxing2,Cui Lunbiao2,Chen Yin2,Xia Xin6,Feng Jialu6,Wang Xue4,Zhao Qi4,Xu XiaoYu7,Li Zhuopei6,Zhang Xiaoyin1,Chen Wei3,Li Jingxin268,Zhu Fengcai1268ORCID

Affiliation:

1. School of Public Health, Southeast University, Nanjing, People’s Republic of China

2. National Health Commission (NHC) Key Laboratory of Enteric Pathogenic Microbiology (Jiangsu Provincial Center for Disease Control and Prevention), Nanjing, People’s Republic of China

3. Beijing Institute of Biotechnology, Academy of Military Medical Sciences, Beijing, People’s Republic of China

4. Cansino Biologics Inc., Tianjin, People’s Republic of China

5. Donghai County Center for Disease Control and Prevention, Lianyungang, Jiangsu, People’s Republic of China

6. School of Public Health, Nanjing Medical University, Nanjing, People’s Republic of China

7. Vazyme Biotech Co., Ltd, Nanjing, People’s Republic of China

8. Institute of Global Public Health and Emergency Pharmacy, China Pharmaceutical University, Nanjing, People’s Republic of China

Funder

National Natural Science Foundation of China

Jiangsu Provincial Science Fund for Distinguished Young Scholars

Key Program of Jiangsu Provincial Science and Technology Plan

National Science Foundation for Excellent Young Scholars of China

Publisher

Informa UK Limited

Subject

Virology,Infectious Diseases,Drug Discovery,General Medicine,Immunology,Microbiology,Parasitology,Epidemiology

Reference26 articles.

1. WHO. WHO coronavirus (COVID-19) dashboard. [cited 2022 Oct 25]. Available from: https://covid19.who.int/?topicsurvey=v8kj13)&gclid=EAIaIQobCIhMxL2d_4Sv-AIVYRLnCh2ZXwaDEAAYASACEgI9y_D_BwE

2. WHO. COVID-10 vaccine tracker. [cited 2022 Oct 19]. Available from: https://covid19.trackvaccines.org/agency/who/

3. SARS-CoV-2 variants of concern and vaccine escape, from Alpha to Omicron and beyond

4. COVID vaccine immunity is waning — how much does that matter?

5. WHO. Interim recommendations for heterologous COVID-19 vaccination schedules. [cited 2022 Oct 14]. Available from: https://www.who.int/news/item/16-12-2021-interim-recommendations-for-heterologous-covid-19-vaccine-schedules

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