Spike mutations contributing to the altered entry preference of SARS-CoV-2 omicron BA.1 and BA.2

Author:

Hu Bingjie1,Chan Jasper Fuk-Woo12345ORCID,Liu Huan1,Liu Yuanchen1,Chai Yue1,Shi Jialu1,Shuai Huiping1,Hou Yuxin1,Huang Xiner1ORCID,Yuen Terrence Tsz-Tai1,Yoon Chaemin1,Zhu Tianrenzheng1,Zhang Jinjin1,Li Wenjun6,Zhang Anna Jinxia13ORCID,Zhou Jie13,Yuan Shuofeng123ORCID,Zhang Bao-Zhong6,Yuen Kwok-Yung12345ORCID,Chu Hin123ORCID

Affiliation:

1. State Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People’s Republic of China

2. Department of Infectious Disease and Microbiology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, People’s Republic of China

3. Centre for Virology, Vaccinology and Therapeutics, Hong Kong Science and Technology Park, Sha Tin, Hong Kong Special Administrative Region, People’s Republic of China

4. Department of Microbiology, Queen Mary Hospital, Pokfulam, Hong Kong Special Administrative Region, People’s Republic of China

5. Academician Workstation of Hainan Province, Hainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, Hainan Medical University, Haikou, People’s Republic of China

6. CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, People’s Republic of China

Funder

Health and Medical Research Fund

Food and Health Bureau

Government of the Hong Kong Special Administrative Region

General Research Fund

Collaborative Research Fund

Theme-Based Research Scheme

Research Grants Council of the Hong Kong Special Administrative Region

Health@InnoHK

Innovation and Technology Commission

National Natural Science Foundation of China

National Program on Key Research Project of China

Enhancing Laboratory Surveillance of Emerging Infectious Diseases

Department of Health of the Hong Kong Special Administrative Region Government

Medicine in Shenzhen

High Level-Hospital Program

Health Commission of Guangdong Province

University of Hong Kong

Major Science and Technology Program of Hainan Province

Hainan Academician Innovation Platform

Hainan Talent Development Project

Emergency Collaborative Project

Emergency COVID-19 Project

Public Security, National Key Research and Development Program

Shaw Foundation Hong Kong

Richard Yu and Carol Yu

May Tam Mak Mei Yin

Michael Seak-Kan Tong

Providence Foundation Limited

Lee Wan Keung Charity Foundation Limited

Hui Ming, Hui Hoy and Chow Sin Lan Charity Fund Limited

Chen Wai Wai Vivien Foundation Limited

Hong Kong Sanatorium & Hospital

Chan Yin Chuen Memorial Charitable Foundation

Marina Man-Wai Lee

Hong Kong Hainan Commercial Association South China Microbiology Research Fund

Jessie & George Ho Charitable Foundation

Perfect Shape Medical Limited

Kai Chong Tong

Foo Oi Foundation Limited

Tse Kam Ming Laurence

Betty Hing-Chu Lee

Ping Cham So

Lo Ying Shek Chi Wai Foundation

Publisher

Informa UK Limited

Subject

Virology,Infectious Diseases,Drug Discovery,General Medicine,Immunology,Microbiology,Parasitology,Epidemiology

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