A novel RBD-protein/peptide vaccine elicits broadly neutralizing antibodies and protects mice and macaques against SARS-CoV-2

Author:

Wang Shixia1,Wang Chang Yi23,Kuo Hui-Kai2,Peng Wen-Jiun2,Huang Juin-Hua2,Kuo Be-Shen3,Lin Feng4,Liu Yaw-Jen3,Liu Zhi4,Wu Huang-Ting2,Ding Shuang4,Hou Kou-Liang2,Cheng Jennifer2,Yang Ya-Ting2,Jiang Ming-Han2,Wang Min-Sheng2,Chen Tony2,Xia Wei Guo4,Lin Ed4,Hung Chung Ho4,Chen Hui-Jung3,Shih Zhonghao3,Lin Yi Ling5,Ryan Valorie1,Hu Mei Mei14,Heppner D. Gray1,Malherbe Delphine C.67,Periasamy Sivakumar67,Kuzmina Natalia67,Subramani Chandru67,Hellerstein Michael1,Monath Thomas P.1,Rumyantsev Alexander1,Bukreyev Alexander687,Guirakhoo Farshad1

Affiliation:

1. Vaxxinity, Inc., Dallas, TX, USA

2. United Biomedical Inc., Asia, Taipei, Taiwan

3. United BioPharma, HuKo, Taiwan

4. United Biomedical Inc., Hauppauge, NY, USA

5. Emerging Infectious Disease Division, Academia Sinica, Nangang, Taiwan

6. Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA

7. Galveston National Laboratory, Galveston, TX, USA

8. Department of Microbiology & Immunology, University of Texas Medical Branch, Galveston, TX, USA

Publisher

Informa UK Limited

Subject

Virology,Infectious Diseases,Drug Discovery,General Medicine,Immunology,Microbiology,Parasitology,Epidemiology

Reference39 articles.

1. The Omicron variant is highly resistant against antibody-mediated neutralization: Implications for control of the COVID-19 pandemic

2. How well can Omicron evade immunity from COVID vaccines?

3. Antibody evasion properties of SARS-CoV-2 Omicron sublineages

4. Control ECfDPa. Epidemiological update: SARS-CoV-2 Omicron sub-lineages BA.4 and BA.5. https://wwwecdceuropaeu/en/news-events/epidemiological-update-sars-cov-2-omicron-sub-lineages-ba4-and-ba5. 2022.

5. https://covid19.trackvaccines.org/. 2022.

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