Key mutations in the C-terminus of the HBV surface glycoprotein correlate with lower HBsAg levels in vivo, hinder HBsAg secretion in vitro and reduce HBsAg structural stability in the setting of HBeAg-negative chronic HBV genotype-D infection-Reference-Cited by-同舟云学术

Key mutations in the C-terminus of the HBV surface glycoprotein correlate with lower HBsAg levels in vivo, hinder HBsAg secretion in vitro and reduce HBsAg structural stability in the setting of HBeAg-negative chronic HBV genotype-D infection

Published:2020-01-01 Issue:1 Volume:9 Page:928-939
ISSN:2222-1751
Container-title:Emerging Microbes & Infections
language:en
Short-container-title:Emerging Microbes & Infections

Author:

Salpini Romina¹,Battisti Arianna²,Piermatteo Lorenzo¹,Carioti Luca¹,Anastasiou Olympia E.³,Gill Upkar S.²,Di Carlo Domenico⁴,Colagrossi Luna⁵,Duca Leonardo¹,Bertoli Ada¹,La Rosa Katia Yu¹,Fabeni Lavinia⁶,Iuvara Alessandra⁷,Malagnino Vincenzo⁸,Cerva Carlotta⁸,Lichtner Miriam⁹,Mastroianni Claudio M.⁹,De Sanctis Giuseppe Maria¹⁰,Paoloni Maurizio¹¹,Marignani Massimo¹²,Pasquazzi Caterina¹²,Iapadre Nerio¹³,Parruti Giustino¹⁴,Vecchiet Jacopo¹⁵,Sarmati Loredana⁸,Andreoni Massimo⁸,Angelico Mario¹⁶,Grelli Sandro¹⁷^ORCID,T. Kennedy Patrick²,Verheyen Jens³,Aquaro Stefano¹⁷,Ceccherini-Silberstein Francesca¹,Perno Carlo Federico¹⁸,Svicher Valentina¹

Affiliation:

1. Department of Experimental Medicine, University of Rome “Tor Vergata”, Rome, Italy

2. Barts Liver Centre, Blizard Institute, Barts and The London SMD, QMUL, London, UK

3. Institute of Virology, University-Hospital, University Duisburg-Essen, Essen, Germany

4. Paediatric Clinical Research Center “Romeo and Enrica Invernizzi”, University of Milan, Milan, Italy

5. Microbiology and Virology Unit, University of Milan, Milan, Italy

6. Laboratory of Virology, National Institute for Infectious Diseases “Lazzaro Spallanzani” -IRCCS, Rome, Italy

7. Microbiology and Virology Unit, Tor Vergata University Hospital, Rome, Italy

8. Infectious Diseases Unit, Tor Vergata University Hospital, Rome, Italy

9. Public Health and Infectious Disease Department, “Sapienza” University, Rome, Italy

10. “Umberto I” University Hospital, Rome, Italy

11. Infectious Disease Unit, “S.S. Filippo e Nicola” Hospital, Avezzano, Italy

12. Department of Gastroenterology, “S. Andrea Hospital”, Rome, Italy

13. “San Salvatore Hospital”, L’ Aquila, Italy

14. Infectious Disease Unit, Pescara General Hospital, Pescara, Italy

15. Department of Medicine and Science of Aging, Clinic of Infectious Diseases, University “G. d'Annunzio” Chieti-Pescara, Chieti, Italy

16. Hepatology Unit, Tor Vergata University Hospital, Rome, Italy

17. Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende, Italy

18. Department of Oncology and Haemato-oncology, University of Milan, Milan, Italy

Funder

FIRB project

National Research Council Italy)

Publisher

Informa UK Limited

Subject

Virology,Infectious Diseases,Drug Discovery,General Medicine,Immunology,Microbiology,Parasitology,Epidemiology

Link

https://www.tandfonline.com/doi/pdf/10.1080/22221751.2020.1757998

Reference33 articles.

1. WHO. Global Hepatitis Report, 2017. (2017). http://apps.who.int/iris/bitstream/handle/10665/255016/9789241565455-eng.pdf;jsessionid=61EC78993CF68B73EEADAA884E757FF0?sequence=1 (accessed 30 Aug 2018).

2. EASL 2017 Clinical Practice Guidelines on the management of hepatitis B virus infection

3. Hepatitis B Surface Antigen Serum Levels Help to Distinguish Active From Inactive Hepatitis B Virus Genotype D Carriers

4. Serum hepatitis B core-related antigen is more accurate than hepatitis B surface antigen to identify inactive carriers, regardless of hepatitis B virus genotype

5. Hepatitis B Virus Genotypes and Variants

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