Neutralization against Omicron subvariants after BA.5/BF.7 breakthrough infection weakened as virus evolution and aging despite repeated prototype-based vaccination 1

Author:

Wang Hongyu1,Xue Quanlin1,Zhang Haocheng1,Yuan Guanmin1,Wang Xun2,Sheng Kai3,Li Chen2,Cai Jianpeng1,Sun Yuhan1,Zhao Jingjing1,Lu Jiahuan3,Fang Shuyu3,Yang Yongfeng4,Zhang Yeting5,Huang Ying6,Wang Jiancui7,Xu Jonathan H.8,Jiang Melissa X.9,Wang Xinyu1,Shen Lei1,Liu Yuanyuan1,Liu Qihui1,Zhang Qiran1,Wang Sen1,Wang Pengfei2,Qiu Chao1,Ai Jingwen1,Zhang Wenhong1101112

Affiliation:

1. Department of Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, National Medical Center for Infectious Diseases, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China

2. Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai Institute of Infectious Disease and Biosecurity, State Key Laboratory of Genetic Engineering, MOE Engineering Research Center of Gene Technology, School of Life Sciences, Fudan University, Shanghai, Shanghai, China

3. Geriatric Department, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China

4. Community Health Service Center of Huaxin Town, Shanghai, People’s Republic of China

5. Community Health Service Center of Chonggu Town, Shanghai, People’s Republic of China

6. Community Health Service Center of Baihe Street, Shanghai, People’s Republic of China

7. Community Health Service Center of Xianghuaqiao Street, Shanghai, People’s Republic of China

8. Shanghai High School International Division, Shanghai, People’s Republic of China

9. Shanghai Pinghe Bilingual School, Shanghai, People’s Republic of China

10. Shanghai Huashen Institute of Microbes and Infections, Shanghai, People’s Republic of China

11. National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, People’s Republic of China

12. Key Laboratory of Medical Molecular Virology (MOE/MOH), Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China

Funder

Shanghai Municipal Science and Technology Major Project

Shanghai Science and Technology Committee

National Natural Science Foundation of China

Research Fund of Shanghai Tongren Hospital, Shanghai Jiaotong University School of Medicine

Shanghai Rising-Star Program

National Key Research and Development Program of China

Publisher

Informa UK Limited

Subject

Virology,Infectious Diseases,Drug Discovery,General Medicine,Immunology,Microbiology,Parasitology,Epidemiology

Reference40 articles.

1. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

2. China CDC. The vaccination status against SARS-CoV-2 in China. [cited 2023 Jul 2]. Available from: https://www.chinacdc.cn/jkzt/crb/zl/szkb_11803/jszl_12208/202301/t20230114_263378.html.

3. People’s Republic of China. WHO Coronavirus Disease (COVID-19) Dashboard with vaccination data. [cited 2023 Apr 11]. Available from: https://covid19.who.int.

4. Efficacy and safety of an inactivated whole-virion SARS-CoV-2 vaccine (CoronaVac): interim results of a double-blind, randomised, placebo-controlled, phase 3 trial in Turkey

5. Effectiveness of the BBIBP-CorV vaccine in preventing infection and death in health care workers in Peru 2021

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