Three neutralizing mAbs induced by MPXV A29L protein recognizing different epitopes act synergistically against orthopoxvirus

Author:

Li Mengjun1,Ren Zuning12,Wang Yuelin1,Jiang Yushan1,Yang Minghui3,Li Delin4,Chen Jiayin1,Liang Zuxin1,Lin Yuhao1,Zeng Zhujun15,Xu Rui5,Wang Yiting6,Zhu Li1,Xiao Weiwei1,Wu Qinghua1,Zhang Bao1,Wan Chengsong1,Yang Yang7,Wu Bo8,Peng Jie2,Zhao Wei1,Shen Chenguang1

Affiliation:

1. BSL-3 Laboratory (Guangdong), Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health; Department of Laboratory Medicine, Zhujiang Hospital; Southern Medical University, Guangzhou, People’s Republic of China

2. State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of China

3. Advanced Research Institute of Multidisciplinary Sciences, Beijing Institute of Technology, Beijing, People’s Republic of China

4. Laboratory of Protein Engineering and Vaccines, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, People’s Republic of China

5. Medical Laboratory Dept, Guangdong Provincial Hospital of Chinese Medicine, Zhuhai, People’s Republic of China

6. Department of Laboratory, Shenzhen Longhua Maternity and Child Healthcare Hospital, Shenzhen, People’s Republic of China

7. Shenzhen Key Laboratory of Pathogen and Immunity, State Key Discipline of Infectious Disease, Shenzhen Third People's Hospital, Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen, People’s Republic of China

8. Hoyotek Biomedical Co., Ltd., Tianjin, People’s Republic of China

Funder

National Natural Science Foundation of China

The Basic Research Project of Key Laboratory of Guangzhou

Guangdong Science and Technology Program key projects

The Guangdong Basic and Applied Basic Research Foundation

Shenzhen Science and Technology Innovation Commission for Research and Development Project

Shenzhen Foundation of Science and Technology

Publisher

Informa UK Limited

Subject

Virology,Infectious Diseases,Drug Discovery,General Medicine,Immunology,Microbiology,Parasitology,Epidemiology

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