A tandem-repeat dimeric RBD protein-based covid-19 vaccine zf2001 protects mice and nonhuman primates

Author:

An Yaling12,Li Shihua2,Jin Xiyue3,Han Jian-bao4,Xu Kun56ORCID,Xu Senyu6,Han Yuxuan12,Liu Chuanyu7,Zheng Tianyi68,Liu Mei9,Yang Mi9,Song Tian-Zhang10,Huang Baoying11,Zhao Li11,Wang Wen11,A Ruhan11,Cheng Yingjie12,Wu Changwei12,Huang Enqi12,Yang Shilong12,Wong Gary1314,Bi Yuhai215ORCID,Ke Changwen16,Tan Wenjie11,Yan Jinghua29ORCID,Zheng Yong-Tang410,Dai Lianpan125ORCID,Gao George F.126118ORCID

Affiliation:

1. Savaid Medical School, University of Chinese Academy of Sciences, Beijing, 101408, People’s Republic of China

2. CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, People’s Republic of China

3. School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, 230026, People’s Republic of China

4. Kunming National High-Level Biosafety Research Center for Non-human Primates, Center for Biosafety Mega-Science, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650107, People’s Republic of China

5. Key Laboratory of Tropical Translational Medicine of Ministry of Education, School of Tropical Medicine and Laboratory Medicine, The First Affiliated Hospital, Hainan Medical University, Hainan, 571199, People’s Republic of China

6. Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing, 100101, People’s Republic of China

7. Laboratory of Animal Infectious Diseases, College of Animal Sciences and Veterinary Medicine, Guangxi University, Nanning, 530000, People’s Republic of China

8. Zhejiang University School of Medicine, Hangzhou 310058, People’s Republic of China

9. CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, People’s Republic of China

10. Key Laboratory of Animal Models and Human Disease Mechanism of the Chinese Academy of Sciences, Kunming Institute of Zoology, Chinese Academic of Sciences, Kunming, 650223, People’s Republic of China

11. NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, People’s Republic of China

12. Anhui Zhifei Longcom Biopharmaceutical Co. Ltd, Anhui, 230088, People’s Republic of China

13. CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, People’s Republic of China

14. Department of Microbiology-Infectiology and Immunology, Laval University, Quebec City G1, Canada

15. CAS Center for Influenza Research and Early-Warning (CASCIRE), CAS-TWAS Center of Excellence for Emerging Infectious Diseases (CEEID), Chinese Academy of Sciences, Beijing, People’s Republic of China

16. Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, People’s Republic of China

Funder

National Program on Key Research Project of China

National Natural Science Foundation of China

NSFC

Youth Innovation Promotion Association

CAS Project for Young Scientists in Basic Research

Publisher

Informa UK Limited

Subject

Virology,Infectious Diseases,Drug Discovery,General Medicine,Immunology,Microbiology,Parasitology,Epidemiology

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