The prominent role of a CDR1 somatic hypermutation for convergent IGHV3-53/3-66 antibodies in binding to SARS-CoV-2-Reference-Cited by-同舟云学术

The prominent role of a CDR1 somatic hypermutation for convergent IGHV3-53/3-66 antibodies in binding to SARS-CoV-2

Published:2022-04-25 Issue:1 Volume:11 Page:1186-1190
ISSN:2222-1751
Container-title:Emerging Microbes & Infections
language:en
Short-container-title:Emerging Microbes & Infections

Author:

Tian Xiaolong¹,Zhu Xiaoyi¹,Song Wenping¹,Yang Zhenlin²³⁴,Wu Yanling¹²^ORCID,Ying Tianlei¹²⁴^ORCID

Affiliation:

1. MOE/NHC Key Laboratory of Medical Molecular Virology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China

2. Shanghai Engineering Research Center for Synthetic Immunology, Shanghai, People’s Republic of China

3. Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of China

4. Shanghai Key Laboratory of Lung Inflammation and Injury, Shanghai, People’s Republic of China

Funder

National Key R&D Program of China

National Natural Science Foundation of China

Publisher

Informa UK Limited

Subject

Virology,Infectious Diseases,Drug Discovery,General Medicine,Immunology,Microbiology,Parasitology,Epidemiology

Link

https://www.tandfonline.com/doi/pdf/10.1080/22221751.2022.2063074

Reference12 articles.

1. Insights into biological therapeutic strategies for COVID-19

2. Sequence signatures of two public antibody clonotypes that bind SARS-CoV-2 receptor binding domain

3. An Alternative Binding Mode of IGHV3-53 Antibodies to the SARS-CoV-2 Receptor Binding Domain

4. Structural basis of a shared antibody response to SARS-CoV-2

5. Functional and structural characterization of a two-MAb cocktail for delayed treatment of enterovirus D68 infections

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2. Deep immunoglobulin repertoire sequencing depicts a comprehensive atlas of spike-specific antibody lineages shared among COVID-19 convalescents;Emerging Microbes & Infections;2024-01-24

3. Breakthrough infection elicits hypermutated IGHV3-53/3-66 public antibodies with broad and potent neutralizing activity against SARS-CoV-2 variants including the emerging EG.5 lineages;PLOS Pathogens;2023-12-04

4. Broadly neutralizing human antibodies against Omicron subvariants of SARS-CoV-2;Journal of Biomedical Science;2023-07-31

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