1. a National Research Institute of Chinese Medicine, Department of Pharmacology , Taipei, 11221, Taiwan
2. b Institute of Traditional Medicine National Yang-Ming University , Taipei, 11221, Taiwan
3. c Veterans General Hospital, Department of Medical Research Taichung , Taichung, 407, Taiwan
4. d Department of Biochemistry
5. e Graduate Institute of Pharmaceutical Sciences Kaohsiung Medical College , Kaohsiung, 807, Taiwan