Contrasting Behavior of Conformationally Locked Carbocyclic Nucleosides of Adenosine and Cytidine as Substrates for Deaminases-Reference-Cited by-同舟云学术

Contrasting Behavior of Conformationally Locked Carbocyclic Nucleosides of Adenosine and Cytidine as Substrates for Deaminases

Published:2009-07-29 Issue:5-7 Volume:28 Page:614-632
ISSN:1525-7770
Container-title:Nucleosides, Nucleotides & Nucleic Acids
language:en
Short-container-title:Nucleosides, Nucleotides & Nucleic Acids

Author:

Marquez Victor E.¹,Schroeder Gottfried K.²,Ludek Olaf R.¹,Siddiqui Maqbool A.¹,Ezzitouni Abdallah¹,Wolfenden Richard²

Affiliation:

1. a Laboratory of Medicinal Chemistry , Center for Cancer Research, National Cancer Institute at Frederick, National Institutes of Health , Frederick , Maryland , USA

2. b Department of Biochemistry and Biophysics , University of North Carolina , Chapel Hill , North Carolina , USA

Publisher

Informa UK Limited

Subject

Genetics,Molecular Medicine,Biochemistry,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/15257770903091904

Reference44 articles.

1. Transition-state stabilization by adenosine deaminase: 1,6-addition of water to purine ribonucleoside, the enzyme's affinity for 6-hydroxy-1,6-dihydropurine ribonucleoside, and the effective concentration of substrate water at the active site

2. Binding of pyrimidin-2-one ribonucleoside by cytidine deaminase as the transition-state analog 3,4-dihydrouridine and contribution of the 4-hydroxyl group to its binding affinity

3. Rates of Spontaneous Disintegration of DNA and the Rate Enhancements Produced by DNA Glycosylases and Deaminases

4. Adenosine deaminase inhibitors: Their role in chemotherapy and immunosuppression

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