Synthesis and Biological Evaluation of (3′S)-3′-Deoxy-3′-Fluoro-3′-C-Ethynylcytidine
Author:
Publisher
Informa UK Limited
Subject
Genetics,Molecular Medicine,Biochemistry,General Medicine
Link
http://www.tandfonline.com/doi/pdf/10.1080/15257770.2011.652753
Reference16 articles.
1. Nucleosides and Nucleotides. 158. 1-(3-C-Ethynyl-β-d-ribo-pentofuranosyl)- cytosine, 1-(3-C-Ethynyl-β-d-ribo-pentofuranosyl)uracil, and Their Nucleobase Analogues as New Potential Multifunctional Antitumor Nucleosides with a Broad Spectrum of Activity
2. An RNA-directed nucleoside anti-metabolite, 1-(3-C-ethynyl-beta-d-ribo-pentofuranosyl)cytosine (ECyd), elicits antitumor effect via TP53-induced Glycolysis and Apoptosis Regulator (TIGAR) downregulation
3. A nucleoside anticancer drug, 1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)cytosine (TAS106), sensitizes cells to radiation by suppressing BRCA2 expression
4. A Simple and Convenient Method for the Selective N-Acylations of Cytosine Nucleosides
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1. ChemInform Abstract: Synthesis and Biological Evaluation of (3′S)-3′-Deoxy-3′-fluoro-3′-C-ethynylcytidine.;ChemInform;2012-10-04
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