Difluoroacetic acid: an alternative acid in the detritylation reaction for the solid-phase synthesis of oligonucleotides-Reference-Cited by-同舟云学术

Difluoroacetic acid: an alternative acid in the detritylation reaction for the solid-phase synthesis of oligonucleotides

Published:2024-04-11 Issue: Volume: Page:1-9
ISSN:1525-7770
Container-title:Nucleosides, Nucleotides & Nucleic Acids
language:en
Short-container-title:Nucleosides, Nucleotides & Nucleic Acids

Author:

Li Quanjian¹,Joshi Dhruval¹,Sanghvi Yogesh S.²,Yan Hongbin¹

Affiliation:

1. Department of Chemistry, Brock University, St. Catharines, Ontario, Canada

2. Rasayan Inc, Encinitas, California, USA

Funder

Natural Sciences and Engineering Research Council of Canada

the Brock-Niagara Validation, Prototyping and Manufacturing Institute

Government of Canada through FedDev Ontario, and Rasayan Inc

Publisher

Informa UK Limited

Link

https://www.tandfonline.com/doi/pdf/10.1080/15257770.2024.2337145

Reference26 articles.

1. Trichloroacetaldehyde modified oligonucleotides

2. Wheeler P.; Capaldi D. C. Methods for detection of chloral hydrate in dichloroacetic acid. PCT WO 02/061138 A1 International Publication Date August 8 2002.

3. Disssociation constants of organic acids in aqueous solution

4. Brown, H. C.; McDaniel, D. H.; Häfliger, O. Chapter 14 - Dissociation Constants. In Determination of Organic Structures by Physical Methods; Braude, E. A., Nachod, F. C., Eds.; Academic Press: NY, 1955; pp 567–662.

5. Synthetic methods and reactions. 63. Pyridinium poly(hydrogen fluoride) (30% pyridine-70% hydrogen fluoride): a convenient reagent for organic fluorination reactions

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1. An expanded framework toward improving the detritylation reaction in solid-phase oligonucleotide syntheses – filling the gap;Nucleosides, Nucleotides & Nucleic Acids;2024-08-09