Design, Enantiopure Synthesis, and Biological Evaluation of Novel ISO-D-2′,3′-Dideoxy-3′-Fluorothianucleoside Derivatives as a bioisostere of Lamivudine-Reference-Cited by-同舟云学术

Design, Enantiopure Synthesis, and Biological Evaluation of Novel ISO-D-2′,3′-Dideoxy-3′-Fluorothianucleoside Derivatives as a bioisostere of Lamivudine

Published:2007-11-26 Issue:8-9 Volume:26 Page:911-915
ISSN:1525-7770
Container-title:Nucleosides, Nucleotides & Nucleic Acids
language:en
Short-container-title:Nucleosides, Nucleotides & Nucleic Acids

Author:

Kim Kyung Ran¹,Park Ah-Young¹,Moon Hyung Ryong¹,Chun Moon Woo²,Jeong Lak Shin³

Affiliation:

1. a College of Pharmacy and Research Institute for Drug Development , Pusan National University , Busan , Korea

2. b College of Pharmacy , Seoul National University , Seoul , Korea

3. c College of Pharmacy , Ewha Womans University , Seoul , Korea

Publisher

Informa UK Limited

Subject

Genetics,Molecular Medicine,Biochemistry,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/15257770701506426

Reference14 articles.

1. Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase.

2. Didanosine

3. Zalcitabine

4. Both 2′,3′-dideoxythymidine and its 2′,3′-unsaturated derivative (2′,3′-dideoxythymidinene) are potent and selective inhibitors of human immunodeficiency virus replication in vitro

5. Anti-human immunodeficiency virus type 1 activity and in vitro toxicity of 2'-deoxy-3'-thiacytidine (BCH-189), a novel heterocyclic nucleoside analog

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