Sensitive liquid chromatography mass spectrometry (LC-MS) assay reveals novel insights on DNA methylation and incorporation of gemcitabine, its metabolite difluorodeoxyuridine, deoxyuridine, and RX-3117 into DNA-Reference-Cited by-同舟云学术

Sensitive liquid chromatography mass spectrometry (LC-MS) assay reveals novel insights on DNA methylation and incorporation of gemcitabine, its metabolite difluorodeoxyuridine, deoxyuridine, and RX-3117 into DNA

Published:2016-12-01 Issue:10-12 Volume:35 Page:652-662
ISSN:1525-7770
Container-title:Nucleosides, Nucleotides & Nucleic Acids
language:en
Short-container-title:Nucleosides, Nucleotides & Nucleic Acids

Author:

Honeywell Richard J.¹,Sarkisjan Dzjemma¹,Kathmann Ietje¹,Kristensen Michael H.²,Peters Godefridus J.¹

Affiliation:

1. Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands

2. Department of Clinical Pathology, Hospital South, Naestved Hospital, Naestved, Zealand Region, Denmark

Publisher

Informa UK Limited

Subject

Genetics,Molecular Medicine,Biochemistry,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/15257770.2016.1216566

Reference21 articles.

1. Novel Developments in the Use of Antimetabolites

2. 2′,2′-Difluoro-deoxycytidine (gemcitabine) incorporation into RNA and DNA of tumour cell lines

3. Antimetabolite incorporation into DNA: Structural and thermodynamic basis for anticancer activity

4. Transport and mode of action of nucleoside derivatives used in chemical and antiviral therapies

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