Design and Synthesis of Novel Carbocyclic Versions of 2′-spirocyclopropyl Ribonucleosides as Potent Anti-HCV Agents
Author:
Affiliation:
1. a Biomaterials Center , Korea Institute of Science and Technology , Seoul, Republic of Korea
2. b BK21-Project Team, College of Pharmacy , Chosun University , Kwangju, Republic of Korea
Publisher
Informa UK Limited
Subject
Genetics,Molecular Medicine,Biochemistry,General Medicine
Link
https://www.tandfonline.com/doi/pdf/10.1080/15257770.2011.587490
Reference27 articles.
1. Viral hepatitis: New data on hepatitis C infection
2. Isolation of a cDNA cLone Derived from a Blood-Borne Non-A, Non-B Viral Hepatitis Genome
3. Hepatitis C: The clinical spectrum of disease
4. Treatment of Hepatitis C in HIV-Coinfected Patients
5. Stereoselective Synthesis and Biological Evaluations of Novel 3′-Deoxy-4′-azaribonucleosides as Inhibitors of Hepatitis C Virus RNA Replication
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1. Spirocyclic Scaffolds in Drug Discovery;Comprehensive Medicinal Chemistry III;2017
2. Nucleoside Inhibitors of Hepatitis C Virus NS5B Polymerase: A Systematic Review;Current Drug Targets;2016-09-02
3. Discovery of 1-((2R,4aR,6R,7R,7aR)-2-Isopropoxy-2-oxidodihydro-4H,6H-spiro[furo[3,2-d][1,3,2]dioxaphosphinine-7,2′-oxetan]-6-yl)pyrimidine-2,4(1H,3H)-dione (JNJ-54257099), a 3′-5′-Cyclic Phosphate Ester Prodrug of 2′-Deoxy-2′-Spirooxetane Uridine Triphosphate Useful for HCV Inhibition;Journal of Medicinal Chemistry;2016-06-03
4. Nucleosides with Modified Sugar Ring: Synthesis and Biological Activities;Current Organic Chemistry;2016-03-03
5. ChemInform Abstract: Design and Synthesis of Novel Carbocyclic Versions of 2′-Spirocyclopropyl Ribonucleosides as Potent anti-HCV Agents.;ChemInform;2011-12-29
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