Synthesis and Antiviral Evaluation of 1-O-Hexadecylpropanediol-3-P-acyclovir: Efficacy Against HSV-1 Infection in Mice-Reference-Cited by-同舟云学术

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Synthesis and Antiviral Evaluation of 1-O-Hexadecylpropanediol-3-P-acyclovir: Efficacy Against HSV-1 Infection in Mice

Published:2000-01 Issue:1-2 Volume:19 Page:471-479
ISSN:1525-7770
Container-title:Nucleosides, Nucleotides and Nucleic Acids
language:en
Short-container-title:Nucleosides, Nucleotides and Nucleic Acids

Author:

Beadle James R.,Kini Ganesh D.,Aldern Kathy A.,Gardner Michael F.,Wright Kristine N.,Rybak Rachel J.,Kern Earl R.,Hostetler Karl Y.

Publisher

Informa UK Limited

Subject

Genetics,Molecular Medicine,Biochemistry,General Medicine

Link

http://www.tandfonline.com/doi/pdf/10.1080/15257770008033022

Reference14 articles.

1. 9-(2-Hydroxyethoxymethyl)guanine activity against viruses of the herpes group

2. Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl)guanine

3. Thymidine kinase from herpes simplex virus phosphorylates the new antiviral compound, 9-(2-hydroxyethoxymethyl)guanine.

4. Phosphorylation of acyclovir diphosphate by cellular enzymes

5. Inhibition of purified human and herpes simplex virus-induced DNA polymerases by 9-(2-hydroxyethoxymethyl)guanine triphosphate. Effects on primer-template function.

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