Styrene lung cancer risk assessment: an alternative evaluation of human lung cancer risk assuming mouse lung tumors are potentially human relevant and operating by a threshold-based non-genotoxic mode of action
Author:
Affiliation:
1. Exponent, Inc, Palo Alto, CA, USA
2. Gradient, Boston, MA, USA
Funder
Styrene Information and Research Center
Publisher
Informa UK Limited
Link
https://www.tandfonline.com/doi/pdf/10.1080/10937404.2024.2380449
Reference64 articles.
1. ACGIH (American Conference of Governmental Industrial Hygienists). 2023. “Styrene.” Threshold Limit Values for Chemical Substances and Physical Agents and Biological Exposure Indices, Cincinnati, OH. ACGIH.
2. IPCS guidelines for the monitoring of genotoxic effects of carcinogens in humans
3. Strain-related differences in mouse lung gene expression over a two-year period of inhalation exposure to styrene: Relevance to human risk assessment
4. Consideration of Styrene Transcriptomic Data Informs Mouse Lung Cyp2F2-Mediated Adverse Outcome Pathway
5. Cancer incidence among Finnish workers exposed to aromatic hydrocarbons
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