Synthesis, crystal structure, hirshfeld surface analysis, molecular docking and molecular dynamics studies of novel olanzapinium 2,5-dihydroxybenzoate as potential and active antipsychotic compound

Author:

Natchimuthu V.1ORCID,Abdalla Mohnad2ORCID,Yadav Manasi3ORCID,Chopra Ishita3ORCID,Bhrdwaj Anushka34ORCID,Sharma Khushboo3ORCID,Ravi S.5ORCID,Ravikumar Krishnan6ORCID,Alzahrani Khalid J.7ORCID,Hussain Tajamul89ORCID,Nayarisseri Anuraj348ORCID

Affiliation:

1. Department of Physics, M.Kumarasamy College of Engineering, Karur, Tamil Nadu, India

2. Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmaceutics, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, PR China

3. In silico Research Laboratory, Eminent Biosciences, Indore, Madhya Pradesh, India

4. Bioinformatics Research Laboratory, LeGene Biosciences Pvt Ltd, Indore, Madhya Pradesh, India

5. PG & Research Department of Physics, National College, Affiliated to Bharathidasan University, Tiruchirapalli, Tamil Nadu, India

6. X-ray Crystallography Division, CSIR-Indian Institute of Chemical Technology(IICT), Hyderabad, India

7. Department of Clinical Laboratories sciences, College of Applied Medical Sciences, Taif University, Taif, Saudi Arabia

8. Research Chair for Biomedical Applications of Nanomaterials, Biochemistry Department, College of Science, King Saud University, Riyadh, Saudi Arabia

9. Center of Excellence in Biotechnology Research, College of Science, King Saud University, Riyadh, Saudi Arabia

Publisher

Informa UK Limited

Subject

General Materials Science,Biomedical Engineering,Bioengineering

Reference179 articles.

1. Systematic meta-review of depot antipsychotic drugs for people with schizophrenia

2. Chakrabarti JK, Hotten TM, Tupper DE. 2-Methyl-10-(4-methyl-1-piperazinyl)-4H-thieno-[2,3-b][1,5]benzodiazepine US Patent No. 5229382 A, 1993.

3. The effects of olanzapine on neurocognitive functioning in medication-refractory schizophrenia

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