Promising drug discovery strategies for sirtuin modulators: what lessons have we learnt?
Author:
Affiliation:
1. Department of Biochemistry, University of Allahabad, Allahabad, India
2. Department of Zoology, Savitribai Phule Pune University, Pune, India
3. Amity Institute of Neuropsychology and Neurosciences, Amity University Uttar Pradesh, Noida, India
Funder
Science and Engineering Research Board
Publisher
Informa UK Limited
Subject
Drug Discovery
Link
https://www.tandfonline.com/doi/pdf/10.1080/17460441.2021.1915980
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1. Mammalian Sirtuins: Biological Insights and Disease Relevance
2. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
3. The Mammalian SIR2α Protein Has a Role in Embryogenesis and Gametogenesis
4. Predominant expression of Sir2α, an NAD-dependent histone deacetylase, in the embryonic mouse heart and brain1
5. Histone H2A.z Is Essential for Cardiac Myocyte Hypertrophy but Opposed by Silent Information Regulator 2α
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