Is PROTAC technology really a game changer for central nervous system drug discovery?-Reference-Cited by-同舟云学术

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Is PROTAC technology really a game changer for central nervous system drug discovery?

Published:2021-04-19 Issue: Volume: Page:1-8
ISSN:1746-0441
Container-title:Expert Opinion on Drug Discovery
language:en
Short-container-title:Expert Opinion on Drug Discovery

Author:

Farrell Kayla¹,Jarome Timothy J.²

Affiliation:

1. Department of Animal and Poultry Sciences, Virginia Polytechnic Institute and State University, VA, USA

2. Department of Animal and Poultry Science and the School of Neuroscience, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA

Funder

National Institutes of Health

Publisher

Informa UK Limited

Subject

Drug Discovery

Link

https://www.tandfonline.com/doi/pdf/10.1080/17460441.2021.1915979

Reference60 articles.

1. Protacs: Chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation

2. Protein Knockdown Using Methyl Bestatin−Ligand Hybrid Molecules: Design and Synthesis of Inducers of Ubiquitination-Mediated Degradation of Cellular Retinoic Acid-Binding Proteins

3. Targeting the von Hippel–Lindau E3 Ubiquitin Ligase Using Small Molecules To Disrupt the VHL/HIF-1α Interaction

4. Phthalimide conjugation as a strategy for in vivo target protein degradation

5. How the ubiquitin–proteasome system controls transcription

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1. Crosstalk between ubiquitination and translation in neurodevelopmental disorders;Frontiers in Molecular Neuroscience;2024-09-02

2. CNS delivery of targeted protein degraders;Journal of Controlled Release;2024-08

3. Ubiquitous regulation of cerebrovascular diseases by ubiquitin‐modifying enzymes;Clinical and Translational Medicine;2024-05

4. Proximity-Induced Pharmacology for Amyloid-Related Diseases;Cells;2024-03-04

5. PROTACs in Treatment of Glioma;PROTAC-Mediated Protein Degradation: A Paradigm Shift in Cancer Therapeutics;2024

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