Preclinical discovery and development of the casirivimab + imdevimab cocktail for the treatment of novel coronavirus infection: the rise and fall

Author:

Tuccori Marco12ORCID,Convertino Irma1ORCID,Ferraro Sara1ORCID,Cappello Emiliano1ORCID,Valdiserra Giulia1ORCID,de Luca Giulia1,Franchini Massimo34ORCID,Focosi DanieleORCID

Affiliation:

1. Unit of Pharmacology and Pharmacovigilance - Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

2. Unit of Adverse Drug Reactions Monitoring, Pisa University Hospital, Pisa, Italy

3. Department of Transfusion Medicine and Hematology, Carlo Poma Hospital Azienda Socio Sanitaria Territoriale of Mantova, Mantova, Italy

4. Tuscany Blood Bank, Pisa University HospitalNorth-Western, Pisa, Italy

Publisher

Informa UK Limited

Subject

Drug Discovery

Reference76 articles.

1. Anti-SARS-CoV-2 neutralizing monoclonal antibodies: clinical pipeline

2. An overview of the preclinical discovery and development of bamlanivimab for the treatment of novel coronavirus infection (COVID-19): reasons for limited clinical use and lessons for the future

3. In vivo monoclonal antibody efficacy against SARS-CoV-2 variant strains

4. Food and Drug Administration. Coronavirus (COVID-19) update: FDA authorizes new long-acting monoclonal antibodies for pre-exposure prevention of COVID-19 in certain individuals. FDA website. https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-authorizes-new-long-acting-monoclonal-antibodies-pre-exposure. Published 2021. cited 2021 Dec 31.

5. Euroepan Medicine Agency. EMA starts rolling review of evusheld (tixagevimab and cilgavimab. EMA website. cited 2021 Dec 31. Available from https://www.ema.europa.eu/en/news/ema-starts-rolling-review-evusheld-tixagevimab-cilgavimab. Published 2021

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