Identifying a predictive relationship between maximal flow rate and viscosity for subcutaneous administration of macromolecules with recombinant human hyaluronidase PH20 in a miniature pig model
Author:
Affiliation:
1. Drug Delivery, Halozyme Therapeutics, Inc., San Diego, CA, USA
2. Formerly of Halozyme Therapeutics, Inc., San Diego, CA, USA
Funder
Halozyme Therapeutics, Inc.
.
Publisher
Informa UK Limited
Subject
Pharmaceutical Science,General Medicine
Link
https://www.tandfonline.com/doi/pdf/10.1080/10717544.2023.2252999
Reference39 articles.
1. Amgen Inc. (2021). Highlights of Prescribing Information. REPATHA (evolcumab) injection for subcutaneous use. https://www.pi.amgen.com/∼/media/amgen/repositorysites/pi-amgen-com/repatha/repatha_pi_hcp_english.pdf [last accessed 23 March 2022].
2. Bittner B, Locke KW, Maneval DC, et al. (2022). ENHANZE® drug delivery technology. Oxford (UK): S. Karger Publishers Ltd.
3. Subcutaneous Administration of Biotherapeutics: An Overview of Current Challenges and Opportunities
4. A recombinant human enzyme for enhanced interstitial transport of therapeutics
5. Hyaluronidase: from clinical applications to molecular and cellular mechanisms
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