Novel compounds protect auditory hair cells against gentamycin-induced apoptosis by maintaining the expression level of H3K4me2

Author:

Li Ao12,You Dan1,Li Wenyan1,Cui Yingjie3,He Yingzi1,Li Wen1,Chen Yan1,Feng Xiao3,Sun Shan1ORCID,Chai Renjie45,Li Huawei16

Affiliation:

1. ENT Institute and Otorhinolaryngology Department of Affiliated Eye and ENT Hospital, Key Laboratory of Hearing Medicine of NHFPC, Shanghai Engineering Research Centre of Cochlear Implant, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China;

2. Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Research Institution of Otorhinolaryngology, Jiangsu Provincial Key Medical Discipline (Laboratory), Nanjing, China;

3. Knowshine (Shanghai) Pharmaceuticals Inc, Shanghai, China;

4. Key Laboratory for Developmental Genes and Human Disease, Ministry of Education, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Institute of Life Sciences, Southeast University, Nanjing, China;

5. Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China;

6. Institutes of Biomedical Sciences and The Institutes of Brain Science and the Collaborative Innovation Center for Brain Science, Fudan University, Shanghai, China

Funder

National Key R&D Program of China

National Natural Science Foundation of China

Natural Science Foundation from Jiangsu Province

Nanjing Medical Science and Technique Development Foundation

Fundamental Research Funds for the Central Universities

Boehringer Ingelheim Pharma GmbH

Yingdong Huo Education Foundation

Publisher

Informa UK Limited

Subject

Pharmaceutical Science,General Medicine

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