Physicochemical properties and micro-interaction between micro-nanoparticles and anterior corneal multilayer biological interface film for improving drug delivery efficacy: the transformation of tear film turnover mode

Author:

Li Huamei1,Dai Fuda1,Liu Hanyu1,Tao Qi2ORCID,Hu Jie1,Zhang Yangrong1,Xiao Zhenping1,Rupenthal Ilva D.3,Li Huihui1,Yang Fan1,Li Wei4,Lin Huaqing1,Hou Dongzhi1ORCID

Affiliation:

1. Guangdong Provincial Key Laboratory of Advanced Drug Delivery Systems and Guangdong Provincial Engineering Center of Topical Precise Drug Delivery System, College of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, Guangdong, China

2. CAS Key Laboratory of Mineralogy and Metallogeny & Guangdong Provincial Key Laboratory of Mineral Physics and Materials, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences (CAS), Guangzhou, P.R. China

3. Buchanan Ocular Therapeutics Unit, Department of Ophthalmology, New Zealand National Eye Centre, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand

4. Guangzhou Institute for Drug Control, Guangzhou, P.R. China

Funder

National Natural Science Foundation of China

Science and Technology Planning Project of Guangdong Province

Publisher

Informa UK Limited

Subject

Pharmaceutical Science,General Medicine

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