Modelling the metabolic action of human and rat CYP1A2 and its relationship with the carcinogenicity of heterocyclic amines
Author:
Affiliation:
1. a REQUIMTE/Departamento de Química, Faculdade de Ciências , Universidade do Porto, Rua do Campo Alegre , 687, 4169-007 , Porto , Portugal
2. b Dipartimento di Chimica , Università di Modena , Via Campi 183, 41100 , Modena , Italy
Publisher
Informa UK Limited
Subject
Physical and Theoretical Chemistry,Condensed Matter Physics,Molecular Biology,Biophysics
Link
https://www.tandfonline.com/doi/pdf/10.1080/00268970310001603112
Reference36 articles.
1. Mammalian Microsomal Cytochrome P450 Monooxygenase
2. Metabolism of 2-Amino-3,8-dimethylimidazo[4,5-f]- quinoxaline in Human Hepatocytes: 2-Amino-3-methylimidazo[4,5-f]quinoxaline-8-carboxylic Acid Is a Major Detoxication Pathway Catalyzed by Cytochrome P450 1A2
3. Interspecies differences in metabolism of heterocyclic aromatic amines by rat and human P450 1A2
4. Substrate recognition sites in cytochrome P450 family 2 (CYP2) proteins inferred from comparative analyses of amino acid and coding nucleotide sequences.
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