A phase IV, open-label three-arm study investigating the impact of a combination of tenofovir disoproxil fumarate/emtricitabine with raltegravir or dolutegravir or elvitegravir/cobicistat on renal function in HIV-1 antiretroviral naïve patients

Author:

Bracchi Margherita1,Pagani Nicole2,Dalla Pria Alessia13,Milinkovic Ana1,Nwokolo NnekaORCID,Thomas Lervina4,Mandalia Sundhyia3,Boffito Marta13,Moyle Graeme1

Affiliation:

1. HIV/GUM, St Stephen's AIDS Trust - Chelsea and Westminster NHS Foundation Trust, London, United Kingdom

2. Royal Brompton Hospital and Harefield NHS Trust, London, United Kingdom

3. Imperial College, London, United Kingdom

4. Guys and St Thomas Hospital, London, United Kingdom

Funder

Merck Sharpe and Dohme, UK

St Stephen’s AIDS Trust

Publisher

Informa UK Limited

Reference65 articles.

1. A Review of Long-Term Toxicity of Antiretroviral Treatment Regimens and Implications for an Aging Population

2. BHIVA guidelines for the treatment of HIV-1-positive adults with ART 2015. Interim update. https://www.bhiva.org/file/RVYKzFwyxpgiI/treatment-guidelines-2016-interim-update.pdf. Updated 2016. Accessed August 8 2021.

3. Guidelines for the use of antiretroviral agents in adults and adolescents with HIV. Department of Health and Human Services. http://aidsinfo.nih.gov/contentfiles/lvguidelines/AdultandAdolescentGL.pdf. Updated March 17 2019. Accessed August 8 2021.

4. Updated recommendations on first-line and second-line antiretroviral regimens and post-exposure prophylaxis and recommendations on early infant diagnosis of HIV: interim guidelines. Supplement to the 2016 consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection (WHO/CDS/HIV/18.5). https://apps.who.int/iris/bitstream/handle/10665/277395/WHO-CDS-HIV-18.51-eng.pdf?ua=1. Published 2018. Updated March 17 2019.

5. Viread summary of product characteristics. https://www.medicines.org.uk/emc/product/1615/smpc. Published 2021. Accessed August 8 2021.

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