1. a Institute for Health and Consumer Protection Joint Research Centre, European Commission , European Centre for the Validation of Alternative Methods (ECVAM) , Ispra , VA , 21020 , Italy
2. b School of Pharmacy and Chemistry Liverpool , John Moores University , Byrom Street, Liverpool , L3 3AF , England UK
3. c Institute for Health and Consumer Protection Joint Research Centre, European Commission , European Chemicals Bureau , Ispra , VA , 21020 , Italy