Generation of a novel fully human non-superagonistic anti-CD28 antibody with efficient and safe T-cell co-stimulation properties

Author:

Elsayed Abdullah12ORCID,Pellegrino Christian3ORCID,Plüss Louis12,Peissert Frederik1,Benz Ramon2,Ulrich Franziska2,Thorhallsdottir Gudrun12ORCID,Plaza Sheila Dakhel1,Villa Alessandra1,Mock Jacqueline1ORCID,Puca Emanuele1ORCID,De Luca Roberto1ORCID,Manz Markus G.3ORCID,Halin Cornelia2ORCID,Neri Dario124ORCID

Affiliation:

1. Philochem AG, Libernstrasse 3, Otelfingen, Switzerland

2. Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology (ETH Zürich), Zurich, Switzerland

3. Department of Medical Oncology and Hematology, University Hospital Zurich and University of Zurich, Zurich, Switzerland

4. Philogen SpA, Siena (S), Italy

Funder

The in vivo safety study was partially supported by Innosuisse Innovation

Publisher

Informa UK Limited

Subject

Immunology,Immunology and Allergy

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