Interrogating heterogeneity of cysteine-engineered antibody-drug conjugates and antibody-oligonucleotide conjugates by capillary zone electrophoresis-mass spectrometry
Author:
Affiliation:
1. Department of Chemistry Michigan State University, East Lansing MI 48824 USA
2. Discovery Biologics, Protein Sciences, Merck & Co., Inc, South San Francisco, CA 94080 USA
Funder
no funding
Publisher
Informa UK Limited
Subject
Immunology,Immunology and Allergy
Link
https://www.tandfonline.com/doi/pdf/10.1080/19420862.2023.2229102
Reference49 articles.
1. Site-specific antibody drug conjugates for cancer therapy
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3. Strategies and challenges for the next generation of antibody–drug conjugates
4. Attachment Site Cysteine Thiol pKa Is a Key Driver for Site-Dependent Stability of THIOMAB Antibody–Drug Conjugates
5. Development of Efficient Chemistry to Generate Site-Specific Disulfide-Linked Protein– and Peptide–Payload Conjugates: Application to THIOMAB Antibody–Drug Conjugates
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