Interrogating heterogeneity of cysteine-engineered antibody-drug conjugates and antibody-oligonucleotide conjugates by capillary zone electrophoresis-mass spectrometry-Reference-Cited by-同舟云学术

Interrogating heterogeneity of cysteine-engineered antibody-drug conjugates and antibody-oligonucleotide conjugates by capillary zone electrophoresis-mass spectrometry

Published:2023-06-28 Issue:1 Volume:15 Page:
ISSN:1942-0862
Container-title:mAbs
language:en
Short-container-title:mAbs

Author:

Xu Tian¹,Zhang Fan²^ORCID,Chen Daoyang²,Sun Liangliang¹,Tomazela Daniela²,Fayadat-Dilman Laurence²

Affiliation:

1. Department of Chemistry Michigan State University, East Lansing MI 48824 USA

2. Discovery Biologics, Protein Sciences, Merck & Co., Inc, South San Francisco, CA 94080 USA

Funder

no funding

Publisher

Informa UK Limited

Subject

Immunology,Immunology and Allergy

Link

https://www.tandfonline.com/doi/pdf/10.1080/19420862.2023.2229102

Reference49 articles.

1. Site-specific antibody drug conjugates for cancer therapy

2. Site-specific Conjugation on Serine → Cysteine Variant Monoclonal Antibodies

3. Strategies and challenges for the next generation of antibody–drug conjugates

4. Attachment Site Cysteine Thiol pKa Is a Key Driver for Site-Dependent Stability of THIOMAB Antibody–Drug Conjugates

5. Development of Efficient Chemistry to Generate Site-Specific Disulfide-Linked Protein– and Peptide–Payload Conjugates: Application to THIOMAB Antibody–Drug Conjugates

Cited by 5 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Imaged capillary isoelectric focusing method development for charge variants of high DAR ADCs;Analytica Chimica Acta;2024-11

2. Precision targeting in oncology: The future of conjugated drugs;Biomedicine & Pharmacotherapy;2024-08

3. Top-down proteomics;Nature Reviews Methods Primers;2024-06-13

4. Intact quantitation of cysteine‐conjugated antibody‐drug conjugates using native mass spectrometry;Rapid Communications in Mass Spectrometry;2024-05-29

5. Development of Prodrug–Payloads for Targeted Therapeutic Applications of Platinum–Acridine Anticancer Agents;Bioconjugate Chemistry;2023-10-09