Design and characterization of homogenous antibody-drug conjugates with a drug-to-antibody ratio of one prepared using an engineered antibody and a dual-maleimide pyrrolobenzodiazepine dimer-Reference-Cited by-同舟云学术

Design and characterization of homogenous antibody-drug conjugates with a drug-to-antibody ratio of one prepared using an engineered antibody and a dual-maleimide pyrrolobenzodiazepine dimer

Published:2019-03-05 Issue:3 Volume:11 Page:500-515
ISSN:1942-0862
Container-title:mAbs
language:en
Short-container-title:mAbs

Author:

White Jason B.¹^ORCID,Fleming Ryan¹,Masterson Luke²^ORCID,Ruddle Ben T.¹^ORCID,Zhong Haihong³,Fazenbaker Christine³^ORCID,Strout Patrick³,Rosenthal Kim¹,Reed Molly⁴,Muniz-Medina Vanessa⁵,Howard Philip²,Dixit Rakesh⁴,Wu Herren¹,Hinrichs Mary Jane⁴^ORCID,Gao Changshou¹,Dimasi Nazzareno¹^ORCID

Affiliation:

1. Antibody Discovery and Protein Engineering, MedImmune, Gaithersburg, MD, USA

2. Spirogen Ltd, QMB Innovation Center, London, UK

3. Oncology Research, MedImmune, Gaithersburg, MD, USA

4. Biologics Safety Assessment, MedImmune, Gaithersburg, MD, USA

5. Biosuperiors, MedImmune, Gaithersburg, MD, USA

Funder

MedImmune, the global biologics R&D arm of AstraZeneca

Publisher

Informa UK Limited

Subject

Immunology,Immunology and Allergy