Discovery of high affinity, pan-allelic, and pan-mammalian reactive antibodies against the myeloid checkpoint receptor SIRPα
Author:
Affiliation:
1. ALX Oncology, Departments of Protein Sciences and Translational Biology, Burlingame, CA, USA
2. Ligand Pharmaceuticals, Inc, Emeryville, CA, USA
3. Helix Biostructures, Columbus, IN, USA
4. Covance Genomics Laboratory, Redmond, WA, USA
Publisher
Informa UK Limited
Subject
Immunology,Immunology and Allergy
Link
https://www.tandfonline.com/doi/pdf/10.1080/19420862.2019.1624123
Reference47 articles.
1. Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential
2. Cancer immunotherapy using checkpoint blockade
3. Roles for Innate Immunity in Combination Immunotherapies
4. “Velcro” Engineering of High Affinity CD47 Ectodomain as Signal Regulatory Protein α (SIRPα) Antagonists That Enhance Antibody-dependent Cellular Phagocytosis
5. The Interaction Between Signal Regulatory Protein Alpha (SIRPα) and CD47: Structure, Function, and Therapeutic Target
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