Characterization and prediction of positional 4-hydroxyproline and sulfotyrosine, two post-translational modifications that can occur at substantial levels in CHO cells-expressed biotherapeutics-Reference-Cited by-同舟云学术

Characterization and prediction of positional 4-hydroxyproline and sulfotyrosine, two post-translational modifications that can occur at substantial levels in CHO cells-expressed biotherapeutics

Published:2019-07-24 Issue:7 Volume:11 Page:1219-1232
ISSN:1942-0862
Container-title:mAbs
language:en
Short-container-title:mAbs

Author:

Tyshchuk Oksana¹,Gstöttner Christoph²^ORCID,Funk Dennis¹^ORCID,Nicolardi Simone²^ORCID,Frost Stefan¹,Klostermann Stefan³,Becker Tim⁴,Jolkver Elena⁴^ORCID,Schumacher Felix¹,Koller Claudia Ferrara⁵^ORCID,Völger Hans Rainer¹,Wuhrer Manfred²^ORCID,Bulau Patrick⁶,Mølhøj Michael¹

Affiliation:

1. Roche Pharma Research and Early Development, Large Molecule Research, Roche Innovation Center Munich, Penzberg, Germany

2. Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, Netherlands

3. Roche Pharma Research and Early Development Informatics, Roche Innovation Center Munich, Penzberg, Germany

4. xValue GmbH, Willich, Germany

5. Roche Pharma Research and Early Development, Large Molecule Research, Roche Innovation Center Zurich, Schlieren, Switzerland

6. Roche Pharma Technical Development Penzberg, Penzberg, Germany

Publisher

Informa UK Limited

Subject

Immunology,Immunology and Allergy

Link

https://www.tandfonline.com/doi/pdf/10.1080/19420862.2019.1635865

Reference51 articles.

1. Macro- and Micro-Heterogeneity of Natural and Recombinant IgG Antibodies

2. Immunogenicity of Biotherapeutics: Causes and Association with Posttranslational Modifications

3. Discovery and characterization of hydroxylysine in recombinant monoclonal antibodies

4. Asparagine-linked Oligosaccharides Present on a Non-consensus Amino Acid Sequence in the CH1 Domain of Human Antibodies

5. Glutamine-linked and Non-consensus Asparagine-linked Oligosaccharides Present in Human Recombinant Antibodies Define Novel Protein Glycosylation Motifs

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