Antibody Fc engineering for enhanced neonatal Fc receptor binding and prolonged circulation half-life
Author:
Affiliation:
1. Biologics Research, Sanofi, Framingham, MA, USA
2. DPMK, Sanofi, Vitry-Sur-Seine, France
3. Biologics Research, Sanofi, Frankurt, Germany
4. Translational Models, Sanofi, Frankurt, Germany
5. Biologics Research, Sanofi, Vitry-Sur-Seine, France
Funder
Sanofi
Publisher
Informa UK Limited
Subject
Immunology,Immunology and Allergy
Link
https://tandfonline.com/doi/pdf/10.1080/19420862.2019.1633883
Reference46 articles.
1. The MHC Class I-Like IgG Receptor Controls Perinatal IgG Transport, IgG Homeostasis, and Fate of IgG-Fc-Coupled Drugs
2. Crystal structure of the complex of rat neonatal Fc receptor with Fc
3. High Resolution Mapping of the Binding Site on Human IgG1 for FcγRI, FcγRII, FcγRIII, and FcRn and Design of IgG1 Variants with Improved Binding to the FcγR
4. Properties of Human IgG1s Engineered for Enhanced Binding to the Neonatal Fc Receptor (FcRn)
5. pH-dependent binding of immunoglobulins to intestinal cells of the neonatal rat.
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