Development of a quantitative relationship between CAR-affinity, antigen abundance, tumor cell depletion and CAR-T cell expansion using a multiscale systems PK-PD model-Reference-Cited by-同舟云学术

Development of a quantitative relationship between CAR-affinity, antigen abundance, tumor cell depletion and CAR-T cell expansion using a multiscale systems PK-PD model

Published:2019-12-18 Issue:1 Volume:12 Page:
ISSN:1942-0862
Container-title:mAbs
language:en
Short-container-title:mAbs

Author:

Singh Aman P.¹^ORCID,Zheng Xirong¹,Lin-Schmidt Xiefan²,Chen Wenbo¹,Carpenter Thomas J.¹,Zong Alice¹,Wang Weirong³,Heald Donald L.¹

Affiliation:

1. Discovery and Translational Research, Biologics Development Sciences, Janssen Biotherapeutics, Spring House, PA, USA

2. Exploratory Biology, Janssen Biotherapeutics, Spring House, PA, USA

3. Clinical Pharmacology and Pharmacometrics, Janssen Research and Development, Spring House, PA, USA

Funder

Janssen Biotherapeutics

Publisher

Informa UK Limited

Subject

Immunology,Immunology and Allergy

Link

https://www.tandfonline.com/doi/pdf/10.1080/19420862.2019.1688616

Reference41 articles.

1. The development of CAR design for tumor CAR-T cell therapy

2. The application of CAR-T cell therapy in hematological malignancies: advantages and challenges

3. Antibody-modified T cells: CARs take the front seat for hematologic malignancies

4. Next Generation CAR T Cells for the Immunotherapy of High-Grade Glioma

5. Long-Term Follow-up of CD19 CAR Therapy in Acute Lymphoblastic Leukemia

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