Physiologically Based Modeling to Predict Monoclonal Antibody Pharmacokinetics in Humans from in vitro Physiochemical Properties
Author:
Affiliation:
1. Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA
2. Department of Exploratory Medicine and Pharmacology, Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN, USA
Funder
National Institutes of Health/National Institute of Biomedical Imaging and Bioengineering
Alfred E. Mann Institute for Biomedical Engineering, University of Southern California
Publisher
Informa UK Limited
Subject
Immunology,Immunology and Allergy
Link
https://www.tandfonline.com/doi/pdf/10.1080/19420862.2022.2056944
Reference58 articles.
1. Next generation antibody drugs: pursuit of the 'high-hanging fruit'
2. Understanding Inter-Individual Variability in Monoclonal Antibody Disposition
3. Heparin chromatography as an in vitro predictor for antibody clearance rate through pinocytosis
4. Toward a Combinatorial Approach for the Prediction of IgG Half-Life and Clearance
5. Establishing in vitro in vivo correlations to screen monoclonal antibodies for physicochemical properties related to favorable human pharmacokinetics
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