Elimination of plasma soluble antigen in cynomolgus monkeys by combining pH-dependent antigen binding and novel Fc engineering-Reference-Cited by-同舟云学术

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Elimination of plasma soluble antigen in cynomolgus monkeys by combining pH-dependent antigen binding and novel Fc engineering

Published:2022-04-28 Issue:1 Volume:14 Page:
ISSN:1942-0862
Container-title:mAbs
language:en
Short-container-title:mAbs

Author:

Hori Yuji¹,Ohmine Ken¹,Katada Hitoshi²,Noguchi Yuki¹,Sato Kazuki¹,Nambu Takeru²,Adeline Lam Runyi²,Wan Gan Siok²^ORCID,Haraya Kenta¹,Ozeki Kazuhisa¹,Nanami Masahiko¹,Tachibana Tatsuhiko¹,Sampei Zenjiro¹,Kuramochi Taichi¹^ORCID,Nezu Junichi³,Hattori Kunihiro⁴,Igawa Tomoyuki³

Affiliation:

1. Research Division, Chugai Pharmaceutical Co, Ltd, Gotemba, Japan

2. Chugai Pharmabody Research Pte. Ltd, Singapore

3. Research Division, Chugai Pharmaceutical Co, Ltd, Chuo-ku, Tokyo, Japan

4. Research Division, Chugai Pharmaceutical Co, Ltd, Kamakura, Japan

Funder

Chugai Pharmaceutical Co., Ltd

Publisher

Informa UK Limited

Subject

Immunology,Immunology and Allergy

Link

https://www.tandfonline.com/doi/pdf/10.1080/19420862.2022.2068213

Reference46 articles.

1. Reviews Preclinical Safety and Immune-Modulating Effects of Therapeutic Monoclonal Antibodies to Interleukin-6 and Tumor Necrosis Factor-α in Cynomolgus Macaques

2. Phase I investigation of recombinant anti-human vascular endothelial growth factor antibody in patients with advanced cancer

3. A randomized controlled trial with an anti-CCL2 (anti–monocyte chemotactic protein 1) monoclonal antibody in patients with rheumatoid arthritis

4. Phase 1 Study of Lumiliximab with Detailed Pharmacokinetic and Pharmacodynamic Measurements in Patients with Relapsed or Refractory Chronic Lymphocytic Leukemia

5. Pharmacokinetics of Anti-hepcidin Monoclonal Antibody Ab 12B9m and Hepcidin in Cynomolgus Monkeys

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1. Impact of structural modifications of IgG antibodies on effector functions;Frontiers in Immunology;2024-01-08

2. Preclinical <i>in vitro</i> evaluation of immune suppression induced by GYM329, Fc-engineered sweeping antibody;The Journal of Toxicological Sciences;2023

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