Comprehensive engineering of a therapeutic neutralizing antibody targeting SARS-CoV-2 spike protein to neutralize escape variants

Author:

Kuramochi Taichi1ORCID,Gan Siok Wan2ORCID,Ho Adrian W.S.2ORCID,Wang Bei3ORCID,Kageji Nagisa4,Nambu Takeru2,Iida Sayaka2,Okuda-Miura Momoko2,Chia Wei Shan2,Yeo Chiew Ying2,Chen Dan2ORCID,Lee Wen-Hsin3ORCID,Ngoh Eve Zi Xian3ORCID,Mohd Salleh Siti Nazihah3ORCID,Wang Cheng-I3ORCID,Igawa Tomoyuki5,Shimada Hideaki2ORCID

Affiliation:

1. Chugai Pharmaceutical Co. Ltd., Fuji Gotemba Research Laboratories, Komakado, Gotemba, Shizuoka, Japan

2. Chugai Pharmabody Research Pte. Ltd., Singapore

3. Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR)

4. Chugai Pharmaceutical Co. Ltd., Kamakura Research Laboratories, Kajiwara, Kamakura, Kanagawa, Japan

5. Chugai Pharmaceutical Co. Ltd., Translational Research Division, Tokyo, Japan

Funder

Chugai Pharmaceutical

Biomedical Research Council

Agency of Science, Technology and Research

Open Access publication charges for this article

Publisher

Informa UK Limited

Subject

Immunology,Immunology and Allergy

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