Impact of S-sulfocysteine on fragments and trisulfide bond linkages in monoclonal antibodies
Author:
Affiliation:
1. Merck Life Sciences, Upstream R&D, Darmstadt, Germany
2. Natural and Medical Sciences Institute (NMI) at the University of Tübingen, Reutlingen, Germany
Publisher
Informa UK Limited
Subject
Immunology,Immunology and Allergy
Link
https://www.tandfonline.com/doi/pdf/10.1080/19420862.2017.1333212
Reference24 articles.
1. Characterisation of a trisulphide derivative of biosynthetic human growth hormone produced in Escherichia coli
2. Detection of traces of a trisulphide derivative in the preparation of a recombinant truncated interleukin-6 mutein
3. Modification of Cysteine 111 in human Cu,Zn-superoxide dismutase
4. Characterization of trisulfide modification in antibodies
5. Evidence for Trisulfide Bonds in a Recombinant Variant of a Human IgG2 Monoclonal Antibody
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