Challenges and opportunities for the future of monoclonal antibody development: Improving safety assessment and reducing animal use

Author:

Sewell Fiona1,Chapman Kathryn1,Couch Jessica2,Dempster Maggie3,Heidel Shawn4,Loberg Lise5ORCID,Maier Curtis3ORCID,Maclachlan Timothy K.6,Todd Marque7,van der Laan Jan Willem89

Affiliation:

1. UK National Centre for the Replacement, Refinement & Reduction of Animals in Research (NC3Rs), London, UK

2. Genentech, Inc., South San Francisco, CA, USA

3. GlaxoSmithKline, King of Prussia, PA, USA

4. Covance Laboratories Ltd, Greenfield, IN, USA

5. AbbVie, Department R46G, North Chicago, IL, USA

6. Novartis, Cambridge, MA, USA

7. Pfizer, Science Center Drive, La Jolla, CA, USA

8. Division of Toxicology, Leiden Academic Center for Drug Research, Leiden University, Leiden, The Netherlands

9. Medicines Evaluation Board, Utrecht, The Netherlands

Publisher

Informa UK Limited

Subject

Immunology,Immunology and Allergy

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