Hydrogen/deuterium exchange mass spectrometry and computational modeling reveal a discontinuous epitope of an antibody/TL1A Interaction-Reference-Cited by-同舟云学术

Hydrogen/deuterium exchange mass spectrometry and computational modeling reveal a discontinuous epitope of an antibody/TL1A Interaction

Published:2017-11-14 Issue:1 Volume:10 Page:95-103
ISSN:1942-0862
Container-title:mAbs
language:en
Short-container-title:mAbs

Author:

Huang Richard Y.-C.¹^ORCID,Krystek Stanley R.²,Felix Nathan³,Graziano Robert F.³,Srinivasan Mohan⁴,Pashine Achal³,Chen Guodong¹

Affiliation:

1. Bioanalytical and Discovery Analytical Sciences, Pharmaceutical Candidate Optimization, Research and Development, Bristol-Myers Squibb Company, Princeton, NJ, USA

2. Molecular Discovery Technologies, Research and Development, Bristol-Myers Squibb Company, Princeton, NJ, USA

3. Discovery Biology, Research and Development, Bristol-Myers Squibb Company, Princeton, NJ, USA

4. Biologics Discovery California, Research and Development, Bristol-Myers Squibb Company, Redwood City, CA, USA

Publisher

Informa UK Limited

Subject

Immunology,Immunology and Allergy

Link

https://www.tandfonline.com/doi/pdf/10.1080/19420862.2017.1393595

Reference41 articles.

1. TL1A Is a TNF-like Ligand for DR3 and TR6/DcR3 and Functions as a T Cell Costimulator

2. Attenuation of Bone Mass and Increase of Osteoclast Formation in Decoy Receptor 3 Transgenic Mice

3. Biologics beyond TNF-αinhibitors and the effect of targeting the homologues TL1A-DR3 pathway in chronic inflammatory disorders

4. TL1A/DR3 axis involvement in the inflammatory cytokine network during pulmonary sarcoidosis

5. Identification of naturally secreted soluble form of TL1A, a TNF-like cytokine

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