Reducing neonatal Fc receptor binding enhances clearance and brain-to-blood ratio of TfR-delivered bispecific amyloid-β antibody

Author:

Schlein Eva1,Andersson Ken G.2,Dallas Tiffany1,Syvänen Stina1ORCID,Sehlin Dag1ORCID

Affiliation:

1. Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden

2. Biotechnology, BioArctic AB, Stockholm, Sweden

Funder

Alzheimerfonden

Gun och Bertil Stohnes Stiftelse

HORIZON EUROPE Marie Sklodowska-Curie Actions

Hjärnfonden

Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse

Magnus Bergvalls Stiftelse

Stiftelsen för Gamla Tjänarinnor

Vetenskapsrådet

Åhlén-stiftelsen

Publisher

Informa UK Limited

Reference54 articles.

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2. Sensitive ELISA detection of amyloid-? protofibrils in biological samples

3. Lecanemab in Early Alzheimer’s Disease

4. Cavazzoni P. (FDA C. for D. E. and R. FDA’s decision to approve new treatment for Alzheimer’s disease. Fda’s decision to approve new treatment for Alzheimer’s disease 2021. https://www.fda.gov/drugs/news-events-human-drugs/fdas-decision-approve-new-treatment-alzheimers-disease.

5. The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

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1. Nuclear Imaging of Bispecific Antibodies on the Rise;Journal of Nuclear Medicine;2024-09-12

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