Nonclinical immunogenicity risk assessment for knobs-into-holes bispecific IgG <sub>1</sub> antibodies-Reference-Cited by-同舟云学术

Nonclinical immunogenicity risk assessment for knobs-into-holes bispecific IgG ₁ antibodies

Published:2024-06-06 Issue:1 Volume:16 Page:
ISSN:1942-0862
Container-title:mAbs
language:en
Short-container-title:mAbs

Author:

Tsai Wen-Ting K.¹^ORCID,Li Yinyin²^ORCID,Yin Zhaojun³,Tran Peter³,Phung Qui⁴^ORCID,Zhou Zhenru⁴,Peng Kun³^ORCID,Qin Dan²,Tam Sien²,Spiess Christoph¹^ORCID,Brumm Jochen⁵^ORCID,Wong Manda⁶^ORCID,Ye Zhengmao²,Wu Patrick³^ORCID,Cohen Sivan³^ORCID,Carter Paul J.¹^ORCID

Affiliation:

1. Department of Antibody Engineering, Genentech, Inc, South San Francisco, CA, USA

2. Department of Biochemical and Cellular Pharmacology, Genentech, Inc, South San Francisco, CA, USA

3. Department of Bioanalytical Sciences, Genentech, Inc, South San Francisco, CA, USA

4. Department of Microchemistry, Proteomics and Lipidomics, Genentech, Inc, South San Francisco, CA, USA

5. Department of Nonclinical Biostatistics, Genentech, Inc, South San Francisco, CA, USA

6. Department of Structural Biology, Genentech, Inc, South San Francisco, CA, USA

Funder

that there is no funding

Publisher

Informa UK Limited

Link

https://www.tandfonline.com/doi/pdf/10.1080/19420862.2024.2362789

Reference63 articles.

1. The Antibody Society. Therapeutic monoclonal antibodies approved or in regulatory review. [accessed 2024 May 31]. www.antibodysociety.org/antibody-therapeutics-product-data.

2. Bispecific antibodies: a mechanistic review of the pipeline

3. A brief introduction of IgG-like bispecific antibody purification: Methods for removing product-related impurities

4. Stable heterodimers from remodeling the domain interface of a homodimer using a phage display library

5. An efficient route to human bispecific IgG