Development of a fully canine anti-canine CTLA4 monoclonal antibody for comparative translational research in dogs with spontaneous tumors-Reference-Cited by-同舟云学术

Development of a fully canine anti-canine CTLA4 monoclonal antibody for comparative translational research in dogs with spontaneous tumors

Published:2021-01-01 Issue:1 Volume:13 Page:
ISSN:1942-0862
Container-title:mAbs
language:en
Short-container-title:mAbs

Author:

Mason Nicola J.¹²³,Chester Nicholas⁴,Xiong Ailian¹,Rotolo Antonia¹,Wu Ying⁵,Yoshimoto Sho¹⁶,Glassman Patrick⁷,Gulendran Gayathri⁸,Siegel Don L.³⁸

Affiliation:

1. Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA

2. Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA

3. Center for Cellular Immunotherapy, Department of Pathology and Laboratory Medicine, School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

4. Vetigenics LLC, Philadelphia, PA, USA

5. Department of Immunobiology, Yale University, New Haven, CT, USA

6. Laboratory of Small Animal Surgery, Department of Veterinary Medicine, School of Veterinary Medicine, Azabu University, Kanagawa, Japan

7. Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

8. Department of Pathology and Laboratory Medicine, School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

Funder

National Cancer Institute

National Heart, Lung, and Blood Institute

Japanese Society for the Promotion of Science

V Foundation for Cancer Research

Publisher

Informa UK Limited

Subject

Immunology,Immunology and Allergy

Link

https://www.tandfonline.com/doi/pdf/10.1080/19420862.2021.2004638

Reference55 articles.

1. Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors

2. CTLA-4 can function as a negative regulator of T cell activation

3. The CD28 and CTLA-4 Receptors Associate with the Serine/Threonine Phosphatase PP2A

4. Regulation of T Cell Receptor Signaling by Tyrosine Phosphatase SYP Association with CTLA-4

5. Confusing signals: Recent progress in CTLA-4 biology

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