Bifunctional molecules targeting SARS-CoV-2 spike and the polymeric Ig receptor display neutralization activity and mucosal enrichment

Author:

White Ian1,Tamot Ninkka1ORCID,Doddareddy Rajitha1,Ho Jason1,Jiao Qun1,Harvilla Paul B.1,Yang Tong-Yuan1,Geist Brian1,Borrok M. Jack1,Truppo Matthew D.2,Ganesan Rajkumar3ORCID,Chowdhury Partha1ORCID,Zwolak Adam1ORCID

Affiliation:

1. Janssen Biotherapeutics, Janssen R&D LLC, Spring House, PA, USA

2. Active Pharmaceutical Ingredient Development, Janssen R&D LLC, Spring House, PA, USA

3. Biologics Discovery, Alector, Inc., South San Francisco, CA, USA

Funder

Janssen Research & Development

Publisher

Informa UK Limited

Subject

Immunology,Immunology and Allergy

Reference62 articles.

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4. Administration USFaD. CDER Scientific Review Documents Supporting Emergency Use Authorizations for Drug and Biological Therapeutic Products | COVID-19. September 25, 2021. https://wwwfdagov/drugs/coronavirus-covid-19-drugs/cder-scientific-review-documents-supporting-emergency-use-authorizations-drug-and-biological

5. IgA, IgG and IgM quantification in bronchoalveolar lavage fluids from allergic rhinitics, allergic asthmatics, and normal subjects by monoclonal antibody-based immunoenzymetric assays

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