Effect of variable domain charge on in vitro and in vivo disposition of monoclonal antibodies-Reference-Cited by-同舟云学术

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Effect of variable domain charge on in vitro and in vivo disposition of monoclonal antibodies

Published:2021-01-01 Issue:1 Volume:13 Page:
ISSN:1942-0862
Container-title:mAbs
language:en
Short-container-title:mAbs

Author:

Liu Shufang¹,Verma Ashwni¹,Kettenberger Hubert²,Richter Wolfgang F.³,Shah Dhaval K.¹^ORCID

Affiliation:

1. Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, the State University of New York at Buffalo, Buffalo, USA

2. Roche Pharma Research and Early Development (Pred), Large Molecule Research (Lmr), Roche Innovation Center Munich, Penzberg, Germany

3. Roche Pharma Research and Early Development (Pred), Pharmaceutical Sciences, Roche Innovation Center Basel, Basel, Switzerland

Funder

associated

Publisher

Informa UK Limited

Subject

Immunology,Immunology and Allergy

Link

https://www.tandfonline.com/doi/pdf/10.1080/19420862.2021.1993769

Reference45 articles.

1. A passionate kiss, then run: exocytosis and recycling of IgG by FcRn

2. A Bottom-Up Whole-Body Physiologically Based Pharmacokinetic Model to Mechanistically Predict Tissue Distribution and the Rate of Subcutaneous Absorption of Therapeutic Proteins

3. Ficoll and dextran vs. globular proteins as probes for testing glomerular permselectivity: effects of molecular size, shape, charge, and deformability

4. Glycoform-resolved pharmacokinetic studies in a rat model employing glycoengineered variants of a therapeutic monoclonal antibody

5. Immunogenicity to Therapeutic Proteins: Impact on PK/PD and Efficacy

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1. Coupling cation and anion exchange chromatography for fast separation of monoclonal antibody charge variants;Journal of Chromatography A;2024-09

2. Internalization of therapeutic antibodies into dendritic cells as a risk factor for immunogenicity;Frontiers in Immunology;2024-08-28

3. Single-domain antibodies and aptamers drive new opportunities for neurodegenerative disease research;Frontiers in Immunology;2024-08-22

4. A systematic review of allometric scaling exponents for IgG mAbs;Xenobiotica;2024-08-07

5. Inter-Antibody Variability in the Clinical Pharmacokinetics of Monoclonal Antibodies Characterized Using Population Physiologically Based Pharmacokinetic Modeling;Antibodies;2024-07-09

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