An accelerated surface-mediated stress assay of antibody instability for developability studies-Reference-Cited by-同舟云学术

An accelerated surface-mediated stress assay of antibody instability for developability studies

Published:2020-01-01 Issue:1 Volume:12 Page:
ISSN:1942-0862
Container-title:mAbs
language:en
Short-container-title:mAbs

Author:

Kopp Marie R.G.¹,Wolf Pérez Adriana-Michelle²³,Zucca Marta Virginia¹,Capasso Palmiero Umberto¹,Friedrichsen Brigitte⁴,Lorenzen Nikolai²,Arosio Paolo¹

Affiliation:

1. Department of Chemistry and Applied Biosciences, Institute for Chemical and Bioengineering, Swiss Federal Institute of Technology, Zurich, Switzerland

2. Department of Biophysics, Biophysics and Injectable Formulation, Novo Nordisk, Måløv, Denmark

3. Aarhus University, iNANO, Aarhus C, Denmark

4. Department of Recombinant Diversity Technologies, Novo Nordisk, Måløv, Denmark

Funder

Innovation Fund Denmark and the STAR program at Novo Nordisk A/S

Publisher

Informa UK Limited

Subject

Immunology,Immunology and Allergy

Link

https://www.tandfonline.com/doi/pdf/10.1080/19420862.2020.1815995

Reference87 articles.

1. Developability Assessment During the Selection of Novel Therapeutic Antibodies

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4. Establishing in vitro in vivo correlations to screen monoclonal antibodies for physicochemical properties related to favorable human pharmacokinetics

5. Engineering the surface properties of a human monoclonal antibody prevents self-association and rapid clearance in vivo

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